The first synthesis of an epidiselenodiketopiperazine.

Org Lett
Authors
Keywords
Abstract

Epidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and similar structural characteristics would be of value to biological investigations. The use of an ETP as the point of departure in the first synthesis of an epidiselenodiketopiperazine (ESeP) and its activity against Mycobacterium tuberculosis (MTB) is reported.

Year of Publication
2012
Journal
Org Lett
Volume
14
Issue
17
Pages
4534-6
Date Published
2012 Sep 07
ISSN
1523-7052
URL
DOI
10.1021/ol3020094
PubMed ID
22913407
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