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Scientific Publications
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Mouse ooplasm confers context-specific reprogramming capacity.
| Publication Type | Journal Article |
| Authors | Chan, MM, Smith ZD, Egli D., Regev A., and Meissner A. |
| Abstract | Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. |
| Year of Publication | 2012 |
| Journal | Nature genetics |
| Volume | 44 |
| Issue | 9 |
| Pages | 978-80 |
| Date Published (YYYY/MM/DD) | 2012/09/01 |
| ISSN Number | 1061-4036 |
| DOI | 10.1038/ng.2382 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22902786?dopt=Abstract |
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