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Mouse ooplasm confers context-specific reprogramming capacity.
|Publication Type||Journal Article|
|Authors||Chan, MM, Smith ZD, Egli D., Regev A., and Meissner A.|
|Abstract||Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.|
|Year of Publication||2012|
|Date Published (YYYY/MM/DD)||2012/09/01|