Scientific Publications

Mouse ooplasm confers context-specific reprogramming capacity.

Publication TypeJournal Article
AuthorsChan, MM, Smith ZD, Egli D., Regev A., and Meissner A.
AbstractEnucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.
Year of Publication2012
JournalNature genetics
Volume44
Issue9
Pages978-80
Date Published (YYYY/MM/DD)2012/09/01
ISSN Number1061-4036
DOI10.1038/ng.2382
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22902786?dopt=Abstract