Recent Broad Publications
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Scientific Publications
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Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.
| Publication Type | Journal Article |
| Authors | Konieczkowski, DJ, and Garraway LA |
| Abstract | Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy. |
| Year of Publication | 2012 |
| Journal | Cell research |
| Date Published (YYYY/MM/DD) | 2012/07/31 |
| ISSN Number | 1001-0602 |
| DOI | 10.1038/cr.2012.115 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22847744?dopt=Abstract |
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