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Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.
|Publication Type||Journal Article|
|Authors||Konieczkowski, DJ, and Garraway LA|
|Abstract||Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy.|
|Year of Publication||2012|
|Date Published (YYYY/MM/DD)||2012/07/31|