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Amino acids and mTORC1: from lysosomes to disease.
|Publication Type||Journal Article|
|Authors||Efeyan, A., Zoncu R., and Sabatini DM|
|Abstract||The mechanistic target of rapamycin (mTOR) kinase controls growth and metabolism, and its deregulation underlies the pathogenesis of many diseases, including cancer, neurodegeneration, and diabetes. mTOR complex 1 (mTORC1) integrates signals arising from nutrients, energy, and growth factors, but how exactly these signals are propagated await to be fully understood. Recent findings have placed the lysosome, a key mediator of cellular catabolism, at the core of mTORC1 regulation by amino acids. A multiprotein complex that includes the Rag GTPases, Ragulator, and the v-ATPase forms an amino acid-sensing machinery on the lysosomal surface that affects the decision between cell growth and catabolism at multiple levels. The involvement of a catabolic organelle in growth signaling may have important implications for our understanding of mTORC1-related pathologies.|
|Year of Publication||2012|
|Journal||Trends in molecular medicine|
|Date Published (YYYY/MM/DD)||2012/06/27|