Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.

Trends Biotechnol
Authors
Keywords
Abstract

For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are changing the scale of data acquisition in behavioral neuroscience. Massive behavioral datasets are beginning to emerge, particularly from zebrafish labs, where behavioral assays can be performed rapidly and reproducibly in 96-well, high-throughput format. Mining these datasets and making comparisons across different assays are major challenges for the field. Here, we review behavioral barcoding, a process by which complex behavioral assays are reduced to a string of numeric features, facilitating analysis and comparison within and across datasets.

Year of Publication
2012
Journal
Trends Biotechnol
Volume
30
Issue
8
Pages
421-5
Date Published
2012 Aug
ISSN
1879-3096
URL
DOI
10.1016/j.tibtech.2012.05.001
PubMed ID
22652049
PubMed Central ID
PMC3401323
Links
Grant list
R21 MH085205 / MH / NIMH NIH HHS / United States
K01MH091449 / MH / NIMH NIH HHS / United States
MH085205 / MH / NIMH NIH HHS / United States
K01 MH091449 / MH / NIMH NIH HHS / United States
T32 HL007208 / HL / NHLBI NIH HHS / United States
T32HL07208 / HL / NHLBI NIH HHS / United States
R01 MH086867 / MH / NIMH NIH HHS / United States
MH086867 / MH / NIMH NIH HHS / United States