Recent Broad Publications
- Hopping between Differentiation States in Lung Adenocarcinoma.
Read More / View Supplemental Materials - Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.
Read More / View Supplemental Materials - The Genome of Anopheles darlingi, the main neotropical malaria vector.
Read More / View Supplemental Materials - ATHLATES: accurate typing of human leukocyte antigen through exome sequencing.
Read More / View Supplemental Materials - Integrated proteomic analysis of post-translational modifications by serial enrichment.
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
Evolutionary diversity of the mitochondrial calcium uniporter.
| Publication Type | Journal Article |
| Authors | Bick, AG, Calvo SE, and Mootha VK |
| Abstract | Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria. |
| Year of Publication | 2012 |
| Journal | Science (New York, N.Y.) |
| Volume | 336 |
| Issue | 6083 |
| Pages | 886 |
| Date Published (YYYY/MM/DD) | 2012/05/18 |
| ISSN Number | 0036-8075 |
| DOI | 10.1126/science.1214977 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22605770?dopt=Abstract |
Share This
- Tweet
