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Inferring carbon sources from gene expression profiles using metabolic flux models.
|Publication Type||Journal Article|
|Authors||Brandes, A., Lun DS, Ip K., Zucker J., Colijn C., Weiner B., and Galagan JE|
|Abstract||Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression with consequent changes in enzyme activity. We report a new method for drawing environmental inferences from gene expression data. Our method prioritizes a list of candidate carbon sources for their compatibility with a gene expression profile using the framework of flux balance analysis to model the organism's metabolic network.|
|Year of Publication||2012|
|Date Published (YYYY/MM/DD)||2012/01/01|