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Inferring carbon sources from gene expression profiles using metabolic flux models.
| Publication Type | Journal Article |
| Authors | Brandes, A., Lun DS, Ip K., Zucker J., Colijn C., Weiner B., and Galagan JE |
| Abstract | Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression with consequent changes in enzyme activity. We report a new method for drawing environmental inferences from gene expression data. Our method prioritizes a list of candidate carbon sources for their compatibility with a gene expression profile using the framework of flux balance analysis to model the organism's metabolic network. |
| Year of Publication | 2012 |
| Journal | PloS one |
| Volume | 7 |
| Issue | 5 |
| Pages | e36947 |
| Date Published (YYYY/MM/DD) | 2012/01/01 |
| DOI | 10.1371/journal.pone.0036947 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22606312?dopt=Abstract |
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