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An image analysis toolbox for high-throughput C. elegans assays.
| Publication Type | Journal Article |
| Authors | Wählby, C., Kamentsky L., Liu ZH, Riklin-Raviv T., Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O., Ljosa V., Irazoqui JE, Golland P., Ruvkun G., Ausubel FM, and Carpenter AE |
| Abstract | We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease. |
| Year of Publication | 2012 |
| Journal | Nature methods |
| Date Published (YYYY/MM/DD) | 2012/04/22 |
| ISSN Number | 1548-7091 |
| DOI | 10.1038/nmeth.1984 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22522656?dopt=Abstract |
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