Scientific Publications

An image analysis toolbox for high-throughput C. elegans assays.

Publication TypeJournal Article
AuthorsWählby, C., Kamentsky L., Liu ZH, Riklin-Raviv T., Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O., Ljosa V., Irazoqui JE, Golland P., Ruvkun G., Ausubel FM, and Carpenter AE
AbstractWe present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.
Year of Publication2012
JournalNature methods
Date Published (YYYY/MM/DD)2012/04/22
ISSN Number1548-7091
DOI10.1038/nmeth.1984
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22522656?dopt=Abstract