Recent Broad Publications
- Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials - Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Read More / View Supplemental Materials - Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
Read More / View Supplemental Materials - Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Read More / View Supplemental Materials - miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
| Publication Type | Journal Article |
| Authors | Youngsaye, W., Dockendorff C., Vincent B., Hartland CL, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. |
| Abstract | Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways. |
| Year of Publication | 2012 |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 22 |
| Issue | 9 |
| Pages | 3362-5 |
| Date Published (YYYY/MM/DD) | 2012/05/01 |
| ISSN Number | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.02.035 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22497765?dopt=Abstract |
Share This
- Tweet
