A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.

Cancer Cell
Authors
Abstract

Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration of a modifiable histone residue in human cancer.

Year of Publication
2012
Journal
Cancer Cell
Volume
21
Issue
3
Pages
329-31
Date Published
2012 Mar 20
ISSN
1878-3686
URL
DOI
10.1016/j.ccr.2012.03.001
PubMed ID
22439930
Links
Grant list
R01 CA057683 / CA / NCI NIH HHS / United States