Recent Broad Publications
- Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials - Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Read More / View Supplemental Materials - Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
Read More / View Supplemental Materials - Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Read More / View Supplemental Materials - miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
| Publication Type | Journal Article |
| Authors | Greulich, H., Chen TH, Feng W., Jänne PA, Alvarez JV, Zappaterra M., Bulmer SE, Frank DA, Hahn WC, Sellers WR, and Meyerson M. |
| Abstract | Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor sensitivity to the EGFR inhibitors erlotinib and gefitinib, but the transforming potential of specific mutations and their relationship to drug sensitivity have not been described. |
| Year of Publication | 2005 |
| Journal | PLoS medicine |
| Volume | 2 |
| Issue | 11 |
| Pages | e313 |
| Date Published (YYYY/MM/DD) | 2005/11/01 |
| ISSN Number | 1549-1277 |
| DOI | 10.1371/journal.pmed.0020313 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/16187797?dopt=Abstract |
Share This
- Tweet
