Scientific Publications

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

Publication TypeJournal Article
AuthorsLee, JC, Vivanco I., Beroukhim R., Huang JH, Feng WL, Debiasi RM, Yoshimoto K., King JC, Nghiemphu P., Yuza Y., Xu Q., Greulich H., Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA, Getz G., Onofrio R., Ziaugra L., Levine RL, Gabriel S., Kawaguchi T., O'Neill K., Khan H., Liau LM, Nelson SF, Rao PN, Mischel P., Pieper RO, Cloughesy T., Leahy DJ, Sellers WR, Sawyers CL, Meyerson M., and Mellinghoff IK
AbstractProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformation, and appear to be a major determinant of response to kinase inhibitor therapy. Missense mutations in the EGFR kinase domain, for example, have recently been identified in patients who showed clinical responses to EGFR kinase inhibitor therapy.
Year of Publication2006
JournalPLoS medicine
Volume3
Issue12
Pagese485
Date Published (YYYY/MM/DD)2006/12/01
ISSN Number1549-1277
DOI10.1371/journal.pmed.0030485
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17177598?dopt=Abstract