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Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.
| Publication Type | Journal Article |
| Authors | Gerszten, RE, Asnani A., and Carr SA |
| Abstract | Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes. |
| Year of Publication | 2011 |
| Journal | Circulation research |
| Volume | 109 |
| Issue | 4 |
| Pages | 463-74 |
| Date Published (YYYY/MM/DD) | 2011/08/05 |
| ISSN Number | 0009-7330 |
| DOI | 10.1161/CIRCRESAHA.110.225003 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21817166?dopt=Abstract |
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