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Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.
|Publication Type||Journal Article|
|Authors||Gerszten, RE, Asnani A., and Carr SA|
|Abstract||Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes.|
|Year of Publication||2011|
|Date Published (YYYY/MM/DD)||2011/08/05|