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Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.
| Publication Type | Journal Article |
| Authors | McElroy, KL, Santiago GA, Lennon NJ, Birren BW, Henn MR, and Muñoz-Jordán JL |
| Abstract | To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution. |
| Year of Publication | 2011 |
| Journal | Emerging infectious diseases |
| Volume | 17 |
| Issue | 1 |
| Pages | 64-71 |
| Date Published (YYYY/MM/DD) | 2011/01/01 |
| ISSN Number | 1080-6040 |
| DOI | 10.3201/eid1701.100961 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21192856?dopt=Abstract |
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