Scientific Publications

The microbial opsin family of optogenetic tools.

Publication TypeJournal Article
AuthorsZhang, F., Vierock J., Yizhar O., Fenno LE, Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P., and Deisseroth K.
AbstractThe capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.
Year of Publication2011
JournalCell
Volume147
Issue7
Pages1446-57
Date Published (YYYY/MM/DD)2011/12/23
ISSN Number0092-8674
DOI10.1016/j.cell.2011.12.004
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22196724?dopt=Abstract