Scientific Publications

Endoplasmic reticulum stress and atherosclerosis.

Publication TypeJournal Article
AuthorsHotamisligil, GS
AbstractAtherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
Year of Publication2010
JournalNature medicine
Volume16
Issue4
Pages396-9
Date Published (YYYY/MM/DD)2010/04/01
ISSN Number1078-8956
DOI10.1038/nm0410-396
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20376052?dopt=Abstract