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Genetic dissection of complex traits with chromosome substitution strains of mice.
| Publication Type | Journal Article |
| Authors | Singer, JB, Hill AE, Burrage LC, Olszens KR, Song J., Justice M., O'Brien WE, Conti DV, Witte JS, Lander E. S., and Nadeau JH |
| Abstract | Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains. |
| Year of Publication | 2004 |
| Journal | Science (New York, N.Y.) |
| Volume | 304 |
| Issue | 5669 |
| Pages | 445-8 |
| Date Published (YYYY/MM/DD) | 2004/04/16 |
| ISSN Number | 0036-8075 |
| DOI | 10.1126/science.1093139 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/15031436?dopt=Abstract |
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