Scientific Publications

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Publication TypeJournal Article
AuthorsSinger, JB, Hill AE, Nadeau JH, and Lander E. S.
AbstractAnxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.
Year of Publication2005
JournalGenetics
Volume169
Issue2
Pages855-62
Date Published (YYYY/MM/DD)2005/02/01
ISSN Number0016-6731
DOI10.1534/genetics.104.031492
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/15371360?dopt=Abstract