Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Genetics
Authors
Keywords
Abstract

Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.

Year of Publication
2005
Journal
Genetics
Volume
169
Issue
2
Pages
855-62
Date Published
2005 Feb
ISSN
0016-6731
URL
DOI
10.1534/genetics.104.031492
PubMed ID
15371360
PubMed Central ID
PMC1449086
Links
Grant list
HD07518 / HD / NICHD NIH HHS / United States
GM07250 / GM / NIGMS NIH HHS / United States
P40 RR012305 / RR / NCRR NIH HHS / United States
RR12305 / RR / NCRR NIH HHS / United States
T32 HD007518 / HD / NICHD NIH HHS / United States
T32 GM007250 / GM / NIGMS NIH HHS / United States