Scientific Publications

Chemical genomics: probing protein function using small molecules.

Publication TypeJournal Article
AuthorsWagner, BK, Haggarty SJ, and Clemons PA
AbstractChemical genomics is concerned with the effects of both genetic variation and chemical perturbation on the cellular effects of small molecules. Chemical genomics relies on selecting biological networks for study, such as those represented by different cell types or disease models, in order to build the desired specificity into the experimental design. The most relevant network property for such experiments is the global connectivity of all cellular proteins comprising the functional ensemble, as illustrated by case studies of the evolution of cyclooxygenase inhibitors and heat-shock protein modulators. Recent examples of chemical genomic profiling, particularly of different cell types, highlight the power of carefully planned experimental approaches in chemical genomics. These new approaches demonstrate the use of the genome to find new targets or new modes of biological interaction.
Year of Publication2011
JournalAmerican journal of pharmacogenomics : genomics-related research in drug development and clinical practice
Volume4
Issue5
Pages313-20
Date Published (YYYY/MM/DD)2011/12/08
ISSN Number1175-2203
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/15462609?dopt=Abstract