Support for involvement of neuregulin 1 in schizophrenia pathophysiology.

Mol Psychiatry
Authors
Keywords
Abstract

Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We tested NRG1 markers and haplotypes for association in 111 parent-proband trios, 321 unrelated cases, and 242 control individuals. Associations were found with a haplotype that overlaps the risk haplotype originally reported in the Icelandic population ("Hap(ICE)"), and two haplotypes located in the 3' end of NRG1 (all P

Year of Publication
2005
Journal
Mol Psychiatry
Volume
10
Issue
4
Pages
366-74, 328
Date Published
2005 Apr
ISSN
1359-4184
URL
DOI
10.1038/sj.mp.4001608
PubMed ID
15545978
Links
Grant list
MH 058693 / MH / NIMH NIH HHS / United States
MH 52618 / MH / NIMH NIH HHS / United States