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A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.
| Publication Type | Journal Article |
| Authors | Poirier, C., Qin Y., Adams CP, Anaya Y., Singer JB, Hill AE, Lander E. S., Nadeau JH, and Bishop CE |
| Abstract | The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo. |
| Year of Publication | 2004 |
| Journal | Genetics |
| Volume | 168 |
| Issue | 3 |
| Pages | 1557-62 |
| Date Published (YYYY/MM/DD) | 2004/11/01 |
| ISSN Number | 0016-6731 |
| DOI | 10.1534/genetics.104.032177 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/15579706?dopt=Abstract |
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