A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.

Genetics
Authors
Keywords
Abstract

The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.

Year of Publication
2004
Journal
Genetics
Volume
168
Issue
3
Pages
1557-62
Date Published
2004 Nov
ISSN
0016-6731
URL
DOI
10.1534/genetics.104.032177
PubMed ID
15579706
PubMed Central ID
PMC1448764
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