A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.
Genetics
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Abstract | The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo. |
Year of Publication | 2004
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Journal | Genetics
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Volume | 168
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Issue | 3
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Pages | 1557-62
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Date Published | 2004 Nov
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ISSN | 0016-6731
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URL | |
DOI | 10.1534/genetics.104.032177
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PubMed ID | 15579706
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PubMed Central ID | PMC1448764
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