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Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.
|Publication Type||Journal Article|
|Authors||Berger, R., Febbo PG, Majumder PK, Zhao JJ, Mukherjee S., Signoretti S., Campbell KT, Sellers WR, Roberts TM, Loda M., Golub T. R., and Hahn WC|
|Abstract||Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate epithelial cells to a luminal phenotype reminiscent of organ-confined prostate cancer when placed in the prostate microenvironment. Moreover, androgen receptor expression converted previously androgen-independent, tumorigenic prostate epithelial cells into cells dependent on testosterone for tumor formation. These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium.|
|Year of Publication||2004|
|Date Published (YYYY/MM/DD)||2004/12/15|