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Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons.
| Publication Type | Journal Article |
| Authors | Oguri, H., and Schreiber SL |
| Abstract | Inspired by the skeletal diversity of naturally occurring indole alkaloids and the rich potential of chemistry developed by Padwa and co-workers, we conceived a pathway entailing six modes of intramolecular reactions leading to indole alkaloid-like skeletons. In this context, an efficient folding pathway via a rhodium-catalyzed tandem cyclization-cycloaddition involving three of the modes has been developed (two of which are shown above) that affords densely functionalized compounds with three distinct skeletons in a stereocontrolled manner. |
| Year of Publication | 2005 |
| Journal | Organic letters |
| Volume | 7 |
| Issue | 1 |
| Pages | 47-50 |
| Date Published (YYYY/MM/DD) | 2005/01/06 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol047945w |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/15624974?dopt=Abstract |
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