Scientific Publications

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons.

Publication TypeJournal Article
AuthorsOguri, H., and Schreiber SL
AbstractInspired by the skeletal diversity of naturally occurring indole alkaloids and the rich potential of chemistry developed by Padwa and co-workers, we conceived a pathway entailing six modes of intramolecular reactions leading to indole alkaloid-like skeletons. In this context, an efficient folding pathway via a rhodium-catalyzed tandem cyclization-cycloaddition involving three of the modes has been developed (two of which are shown above) that affords densely functionalized compounds with three distinct skeletons in a stereocontrolled manner.
Year of Publication2005
JournalOrganic letters
Volume7
Issue1
Pages47-50
Date Published (YYYY/MM/DD)2005/01/06
ISSN Number1523-7060
DOI10.1021/ol047945w
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/15624974?dopt=Abstract