Scientific Publications

DNA polymorphism detector: an automated tool that searches for allelic matches in public databases for discrepancies found in clone or cDNA sequences.

Publication TypeJournal Article
AuthorsChang, CY, and LaBaer J.
AbstractSUMMARY: DNA polymorphism detector (DPD) is a new web application developed to help automate the process of cDNA clone validation. DPD identifies and highlights discrepancies between any cDNA clone sequence and its expected reference sequence. To determine if these differences correspond to natural genetic polymorphisms (versus artifacts introduced during clone production or evaluation), DPD uses the discrepancies, along with flanking sequences, to search GenBank for identical matching strings. If matching DNA sequences are found, DPD verifies that they are from the same gene. The application then reports the discrepancy as a polymorphism along with the corresponding GenBank reference information. AVAILABILITY: DPD is currently hosted by the Harvard Institute of Proteomics at http://www.hip.harvard.edu
Year of Publication2005
JournalBioinformatics (Oxford, England)
Volume21
Issue9
Pages2133-5
Date Published (YYYY/MM/DD)2005/05/01
ISSN Number1367-4803
DOI10.1093/bioinformatics/bti298
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/15695424?dopt=Abstract