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Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.
| Publication Type | Journal Article |
| Authors | Butcher, RA, and Schreiber SL |
| Abstract | Transcriptional profiling with DNA microarrays can be used to measure the genome-wide transcriptional response to small molecules. Recent progress in the analysis of gene-expression data has relied on the generation of databases of profiles documenting the transcriptional effects of various compound treatments and genetic perturbations. A positive correlation between the transcriptional response induced by a novel small molecule and a database profile can provide insight into the molecule's mechanism. Transcriptional profiling can also be used to assess a small molecule's specificity for its target and to facilitate analysis of pathways downstream of the target. |
| Year of Publication | 2005 |
| Journal | Current opinion in chemical biology |
| Volume | 9 |
| Issue | 1 |
| Pages | 25-30 |
| Date Published (YYYY/MM/DD) | 2005/02/01 |
| ISSN Number | 1367-5931 |
| DOI | 10.1016/j.cbpa.2004.10.009 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/15701449?dopt=Abstract |
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