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Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.
|Publication Type||Journal Article|
|Authors||Butcher, RA, and Schreiber SL|
|Abstract||Transcriptional profiling with DNA microarrays can be used to measure the genome-wide transcriptional response to small molecules. Recent progress in the analysis of gene-expression data has relied on the generation of databases of profiles documenting the transcriptional effects of various compound treatments and genetic perturbations. A positive correlation between the transcriptional response induced by a novel small molecule and a database profile can provide insight into the molecule's mechanism. Transcriptional profiling can also be used to assess a small molecule's specificity for its target and to facilitate analysis of pathways downstream of the target.|
|Year of Publication||2005|
|Journal||Current opinion in chemical biology|
|Date Published (YYYY/MM/DD)||2005/02/01|