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Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.
| Publication Type | Journal Article |
| Authors | Mazitschek, R., Huwe A., and Giannis A. |
| Abstract | A promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumour can neither grow to a life threatening size, nor metastasize. The natural product fumagillin 1 and the structurally related ovalicin 2 are two of the most potent anti-angiogenic compounds. Here, we report the design and synthesis of novel fumagillin and ovalicin analogues lacking reactive epoxy functionalities, which were thought to be responsible for the severe toxic side-effects observed. We also report a new synthetic approach and the determination of the anti-angiogenic properties of these compounds in endothelial cells. |
| Year of Publication | 2005 |
| Journal | Organic & biomolecular chemistry |
| Volume | 3 |
| Issue | 11 |
| Pages | 2150-4 |
| Date Published (YYYY/MM/DD) | 2005/06/07 |
| ISSN Number | 1477-0520 |
| DOI | 10.1039/b503163j |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/15917904?dopt=Abstract |
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