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Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.
|Publication Type||Journal Article|
|Authors||Mazitschek, R., Huwe A., and Giannis A.|
|Abstract||A promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumour can neither grow to a life threatening size, nor metastasize. The natural product fumagillin 1 and the structurally related ovalicin 2 are two of the most potent anti-angiogenic compounds. Here, we report the design and synthesis of novel fumagillin and ovalicin analogues lacking reactive epoxy functionalities, which were thought to be responsible for the severe toxic side-effects observed. We also report a new synthetic approach and the determination of the anti-angiogenic properties of these compounds in endothelial cells.|
|Year of Publication||2005|
|Journal||Organic & biomolecular chemistry|
|Date Published (YYYY/MM/DD)||2005/06/07|