Scientific Publications

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.

Publication TypeJournal Article
AuthorsMazitschek, R., Huwe A., and Giannis A.
AbstractA promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumour can neither grow to a life threatening size, nor metastasize. The natural product fumagillin 1 and the structurally related ovalicin 2 are two of the most potent anti-angiogenic compounds. Here, we report the design and synthesis of novel fumagillin and ovalicin analogues lacking reactive epoxy functionalities, which were thought to be responsible for the severe toxic side-effects observed. We also report a new synthetic approach and the determination of the anti-angiogenic properties of these compounds in endothelial cells.
Year of Publication2005
JournalOrganic & biomolecular chemistry
Volume3
Issue11
Pages2150-4
Date Published (YYYY/MM/DD)2005/06/07
ISSN Number1477-0520
DOI10.1039/b503163j
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/15917904?dopt=Abstract