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Place of pattern in proteomic biomarker discovery.
|Publication Type||Journal Article|
|Authors||Gillette, MA, Mani D. R., and Carr SA|
|Abstract||The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.|
|Year of Publication||1969|
|Journal||Journal of proteome research|
|Date Published (YYYY/MM/DD)||2005/1/1|