DNA sequence and analysis of human chromosome 18.

Nature
Authors
Keywords
Abstract

Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.

Year of Publication
2005
Journal
Nature
Volume
437
Issue
7058
Pages
551-5
Date Published
2005 Sep 22
ISSN
1476-4687
URL
DOI
10.1038/nature03983
PubMed ID
16177791
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