Recent Broad Publications
- Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials - Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Read More / View Supplemental Materials - Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
Read More / View Supplemental Materials - Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Read More / View Supplemental Materials - miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.
| Publication Type | Journal Article |
| Authors | Urgaonkar, S., La Pierre HS, Meir I., Lund H., Raychaudhuri D., and Shaw JT |
| Abstract | [chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis. |
| Year of Publication | 2005 |
| Journal | Organic letters |
| Volume | 7 |
| Issue | 25 |
| Pages | 5609-12 |
| Date Published (YYYY/MM/DD) | 2005/12/08 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol052269z |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/16321003?dopt=Abstract |
Share This
- Tweet
