Scientific Publications

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Publication TypeJournal Article
AuthorsUrgaonkar, S., La Pierre HS, Meir I., Lund H., Raychaudhuri D., and Shaw JT
Abstract[chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
Year of Publication2005
JournalOrganic letters
Volume7
Issue25
Pages5609-12
Date Published (YYYY/MM/DD)2005/12/08
ISSN Number1523-7060
DOI10.1021/ol052269z
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/16321003?dopt=Abstract