Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.
Org Lett
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Abstract | [chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis. |
Year of Publication | 2005
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Journal | Org Lett
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Volume | 7
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Issue | 25
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Pages | 5609-12
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Date Published | 2005 Dec 08
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ISSN | 1523-7060
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URL | |
DOI | 10.1021/ol052269z
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PubMed ID | 16321003
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PubMed Central ID | PMC2588422
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Grant list | R03 AI062905 / AI / NIAID NIH HHS / United States
R03 AI062905-01 / AI / NIAID NIH HHS / United States
R03 AI062905-02 / AI / NIAID NIH HHS / United States
R01GM068025 / GM / NIGMS NIH HHS / United States
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