Scientific Publications

Macrocycloadditions leading to conformationally restricted small molecules.

Publication TypeJournal Article
AuthorsLooper, RE, Pizzirani D., and Schreiber SL
Abstract[reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.
Year of Publication2006
JournalOrganic letters
Volume8
Issue10
Pages2063-6
Date Published (YYYY/MM/DD)2006/05/11
ISSN Number1523-7060
DOI10.1021/ol0604724
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/16671782?dopt=Abstract