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Macrocycloadditions leading to conformationally restricted small molecules.
| Publication Type | Journal Article |
| Authors | Looper, RE, Pizzirani D., and Schreiber SL |
| Abstract | [reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents. |
| Year of Publication | 2006 |
| Journal | Organic letters |
| Volume | 8 |
| Issue | 10 |
| Pages | 2063-6 |
| Date Published (YYYY/MM/DD) | 2006/05/11 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol0604724 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/16671782?dopt=Abstract |
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