Scientific Publications

Coevolution, modularity and human disease.

Publication TypeJournal Article
AuthorsFraser, HB
AbstractThe concepts of coevolution and modularity have been studied separately for decades. Recent advances in genomics have led to the first systematic studies in each of these fields at the molecular level, resulting in several important discoveries. Both coevolution and modularity appear to be pervasive features of genomic data from all species studied to date, and their presence can be detected in many types of datasets, including genome sequences, gene expression data, and protein-protein interaction data. Moreover, the combination of these two ideas might have implications for our understanding of many aspects of biology, ranging from the general architecture of living systems to the causes of various human diseases.
Year of Publication2006
JournalCurrent opinion in genetics & development
Volume16
Issue6
Pages637-44
Date Published (YYYY/MM/DD)2006/12/01
ISSN Number0959-437X
DOI10.1016/j.gde.2006.09.001
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17005391?dopt=Abstract