Scientific Publications

Transferability of tag SNPs in genetic association studies in multiple populations.

Publication TypeJournal Article
Authorsde Bakker, PI, Burtt NP, Graham RR, Guiducci C., Yelensky R., Drake JA, Bersaglieri T., Penney KL, Butler J., Young S., Onofrio RC, Lyon HN, Stram DO, Haiman CA, Freedman ML, Zhu X., Cooper R., Groop L., Kolonel LN, Henderson BE, Daly M. J., Hirschhorn JN, and Altshuler D.
AbstractA general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four HapMap population samples and eleven other population samples. We picked tag SNPs using genotype data we collected in the HapMap samples and then evaluated the effective coverage of these tags in comparison to the entire set of common variants observed in the other samples. We simulated case-control association studies in the non-HapMap samples under a disease model of modest risk, and we observed little loss in power. These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world.
Year of Publication2006
JournalNature genetics
Volume38
Issue11
Pages1298-303
Date Published (YYYY/MM/DD)2006/11/01
ISSN Number1061-4036
DOI10.1038/ng1899
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17057720?dopt=Abstract