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SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Publication TypeJournal Article
AuthorsDuan, Z., Bradner JE, Greenberg E., LeVine R., Foster R., Mahoney J., and Seiden MV
AbstractSignal transducer and activator of transcription 3 (Stat3) proteins have important roles in cancer cell survival and proliferation. Recent studies show that aberrant Stat3 activation promotes tumor growth and survival in several human cancers, and thus, presents an attractive pathway for the development of targeted anticancer therapy. Stat3 is a DNA-binding transcription factor, and thus, its function depends on cytoplasmic to nuclear translocation. To discover novel inhibitors of the Stat3 signaling pathway, we designed a cell-based screening assay capable of identifying compounds that inhibit Stat3 nuclear translocation and activity.
Year of Publication2006
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume12
Issue22
Pages6844-52
Date Published (YYYY/MM/DD)2006/11/15
ISSN Number1078-0432
DOI10.1158/1078-0432.CCR-06-1330
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17121906?dopt=Abstract