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A pipeline for ligand discovery using small-molecule microarrays.
| Publication Type | Journal Article |
| Authors | Duffner, JL, Clemons PA, and Koehler AN |
| Abstract | Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs. |
| Year of Publication | 2007 |
| Journal | Current opinion in chemical biology |
| Volume | 11 |
| Issue | 1 |
| Pages | 74-82 |
| Date Published (YYYY/MM/DD) | 2007/02/01 |
| ISSN Number | 1367-5931 |
| DOI | 10.1016/j.cbpa.2006.11.031 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/17169601?dopt=Abstract |
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