Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Science
Authors
Keywords
Abstract

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.

Year of Publication
2007
Journal
Science
Volume
316
Issue
5829
Pages
1331-6
Date Published
2007 Jun 01
ISSN
1095-9203
URL
DOI
10.1126/science.1142358
PubMed ID
17463246
Links
Grant list
K23 DK65978-04 / DK / NIDDK NIH HHS / United States
K23 DK080145 / DK / NIDDK NIH HHS / United States
K23 DK080145-01 / DK / NIDDK NIH HHS / United States
U01 HG004171 / HG / NHGRI NIH HHS / United States
K23-HL083102 / HL / NHLBI NIH HHS / United States
F32 DK079466 / DK / NIDDK NIH HHS / United States
F32 DK079466-01 / DK / NIDDK NIH HHS / United States
K23 DK067288 / DK / NIDDK NIH HHS / United States