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Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.
|Publication Type||Journal Article|
|Authors||Peng, LF, Kim SS, Matchacheep S., Lei X., Su S., Lin W., Runguphan W., Choe WH, Sakamoto N., Ikeda M., Kato N., Beeler AB, Porco JA Jr, Schreiber SL, and Chung RT|
|Abstract||Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.|
|Year of Publication||2007|
|Journal||Antimicrobial agents and chemotherapy|
|Date Published (YYYY/MM/DD)||2007/10/01|