Recent Broad Publications
- Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials - Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Read More / View Supplemental Materials - Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
Read More / View Supplemental Materials - Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Read More / View Supplemental Materials - miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.
| Publication Type | Journal Article |
| Authors | Peng, LF, Kim SS, Matchacheep S., Lei X., Su S., Lin W., Runguphan W., Choe WH, Sakamoto N., Ikeda M., Kato N., Beeler AB, Porco JA Jr, Schreiber SL, and Chung RT |
| Abstract | Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity. |
| Year of Publication | 2007 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 51 |
| Issue | 10 |
| Pages | 3756-9 |
| Date Published (YYYY/MM/DD) | 2007/10/01 |
| ISSN Number | 0066-4804 |
| DOI | 10.1128/AAC.00233-07 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/17682098?dopt=Abstract |
Share This
- Tweet
