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Scientific Publications
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Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.
| Publication Type | Journal Article |
| Authors | Wei, J., and Shaw JT |
| Abstract | A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct. |
| Year of Publication | 2007 |
| Journal | Organic letters |
| Volume | 9 |
| Issue | 20 |
| Pages | 4077-80 |
| Date Published (YYYY/MM/DD) | 2007/09/27 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol701911u |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/17760458?dopt=Abstract |
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