Scientific Publications

Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.

Publication TypeJournal Article
AuthorsWei, J., and Shaw JT
AbstractA new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
Year of Publication2007
JournalOrganic letters
Volume9
Issue20
Pages4077-80
Date Published (YYYY/MM/DD)2007/09/27
ISSN Number1523-7060
DOI10.1021/ol701911u
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17760458?dopt=Abstract