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Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.
|Publication Type||Journal Article|
|Authors||Wei, J., and Shaw JT|
|Abstract||A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.|
|Year of Publication||2007|
|Date Published (YYYY/MM/DD)||2007/09/27|