Recent Broad Publications
- Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials - Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
Read More / View Supplemental Materials - Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
Read More / View Supplemental Materials - Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Read More / View Supplemental Materials - miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Read More / View Supplemental Materials
Scientific Publications
< Back to Publications
N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.
| Publication Type | Journal Article |
| Authors | Mukherjee, S., Robinson CA, Howe AG, Mazor T., Wood PA, Urgaonkar S., Hebert AM, Raychaudhuri D., and Shaw JT |
| Abstract | A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20+/-5% at 100microM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound. |
| Year of Publication | 2007 |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 17 |
| Issue | 23 |
| Pages | 6651-5 |
| Date Published (YYYY/MM/DD) | 2007/12/01 |
| ISSN Number | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.09.010 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/17923406?dopt=Abstract |
Share This
- Tweet
