Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Nat Genet
Authors
Keywords
Abstract

To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in comparison to publicly available genotype data for 1,211 related individuals from the Framingham Heart Study. After evaluating and adjusting for technical and population biases, we identified a SNP at 6q23 (rs10499194, approximately 150 kb from TNFAIP3 and OLIG3) that was reproducibly associated with rheumatoid arthritis both in the genome-wide association (GWA) scan and in 5,541 additional case-control samples (P = 10(-3), GWA scan; P

Year of Publication
2007
Journal
Nat Genet
Volume
39
Issue
12
Pages
1477-82
Date Published
2007 Dec
ISSN
1546-1718
URL
DOI
10.1038/ng.2007.27
PubMed ID
17982456
PubMed Central ID
PMC2652744
Links
Grant list
R01-AR44422 / AR / NIAMS NIH HHS / United States
K08 AI055314-03 / AI / NIAID NIH HHS / United States
R01 AR044422 / AR / NIAMS NIH HHS / United States
K08 AI055314-02 / AI / NIAID NIH HHS / United States
K08 AI055314-01A1 / AI / NIAID NIH HHS / United States
K08 AI055314-05 / AI / NIAID NIH HHS / United States
N01-AR-2-2263 / AR / NIAMS NIH HHS / United States
AI55314-3 / AI / NIAID NIH HHS / United States
K08 AI055314 / AI / NIAID NIH HHS / United States
K08 AI055314-04 / AI / NIAID NIH HHS / United States