Gene expression-based screening for inhibitors of PDGFR signaling.

Genome Biol
Authors
Keywords
Abstract

Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest.

Year of Publication
2008
Journal
Genome Biol
Volume
9
Issue
3
Pages
R47
Date Published
2008
ISSN
1474-760X
URL
DOI
10.1186/gb-2008-9-3-r47
PubMed ID
18312689
PubMed Central ID
PMC2397499
Links
Grant list
R01 CA097061 / CA / NCI NIH HHS / United States
CA97061 / CA / NCI NIH HHS / United States
Howard Hughes Medical Institute / United States