Gene expression-based screening for inhibitors of PDGFR signaling.
Genome Biol
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Abstract | Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest. |
Year of Publication | 2008
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Journal | Genome Biol
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Volume | 9
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Issue | 3
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Pages | R47
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Date Published | 2008
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ISSN | 1474-760X
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URL | |
DOI | 10.1186/gb-2008-9-3-r47
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PubMed ID | 18312689
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PubMed Central ID | PMC2397499
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Grant list | R01 CA097061 / CA / NCI NIH HHS / United States
CA97061 / CA / NCI NIH HHS / United States
Howard Hughes Medical Institute / United States
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