Scientific Publications

Cross-kingdom patterns of alternative splicing and splice recognition.

Publication TypeJournal Article
AuthorsMcGuire, AM, Pearson MD, Neafsey DE, and Galagan JE
AbstractVariations in transcript splicing can reveal how eukaryotes recognize intronic splice sites. Retained introns (RIs) commonly appear when the intron definition (ID) mechanism of splice site recognition inconsistently identifies intron-exon boundaries, and cassette exons (CEs) are often caused by variable recognition of splice junctions by the exon definition (ED) mechanism. We have performed a comprehensive survey of alternative splicing across 42 eukaryotes to gain insight into how spliceosomal introns are recognized.
Year of Publication2012
JournalGenome biology
Volume9
Issue3
PagesR50
Date Published (YYYY/MM/DD)2012/01/05
ISSN Number1465-6906
DOI10.1186/gb-2008-9-3-r50
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18321378?dopt=Abstract