Scientific Publications

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.

Publication TypeJournal Article
AuthorsSetlur, SR, Mertz KD, Hoshida Y., Demichelis F., Lupien M., Perner S., Sboner A., Pawitan Y., Andrén O., Johnson LA, Tang J., Adami HO, Calza S., Chinnaiyan AM, Rhodes D., Tomlins S., Fall K., Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E., Johansson JE, Brown M., Golub T. R., and Rubin MA
AbstractThe majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation-specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate cancer defined by this fusion.
Year of Publication2008
JournalJournal of the National Cancer Institute
Volume100
Issue11
Pages815-25
Date Published (YYYY/MM/DD)2008/06/04
ISSN Number0027-8874
DOI10.1093/jnci/djn150
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18505969?dopt=Abstract