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Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
| Publication Type | Journal Article |
| Authors | Setlur, SR, Mertz KD, Hoshida Y., Demichelis F., Lupien M., Perner S., Sboner A., Pawitan Y., Andrén O., Johnson LA, Tang J., Adami HO, Calza S., Chinnaiyan AM, Rhodes D., Tomlins S., Fall K., Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E., Johansson JE, Brown M., Golub T. R., and Rubin MA |
| Abstract | The majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation-specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate cancer defined by this fusion. |
| Year of Publication | 2008 |
| Journal | Journal of the National Cancer Institute |
| Volume | 100 |
| Issue | 11 |
| Pages | 815-25 |
| Date Published (YYYY/MM/DD) | 2008/06/04 |
| ISSN Number | 0027-8874 |
| DOI | 10.1093/jnci/djn150 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/18505969?dopt=Abstract |
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