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Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

Publication TypeJournal Article
AuthorsHoshida, Y., Villanueva A., Kobayashi M., Peix J., Chiang DY, Camargo A., Gupta S., Moore J., Wrobel MJ, Lerner J., Reich M., Chan JA, Glickman JN, Ikeda K., Hashimoto M., Watanabe G., Daidone MG, Roayaie S., Schwartz M., Thung S., Salvesen HB, Gabriel S., Mazzaferro V., Bruix J., Friedman SL, Kumada H., Llovet JM, and Golub T. R.
AbstractIt is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissue.
Year of Publication2008
JournalThe New England journal of medicine
Volume359
Issue19
Pages1995-2004
Date Published (YYYY/MM/DD)2008/11/06
ISSN Number0028-4793
DOI10.1056/NEJMoa0804525
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18923165?dopt=Abstract