Scientific Publications

Genetic mapping in human disease.

Publication TypeJournal Article
AuthorsAltshuler, D., Daly M. J., and Lander E. S.
AbstractGenetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
Year of Publication2008
JournalScience (New York, N.Y.)
Volume322
Issue5903
Pages881-8
Date Published (YYYY/MM/DD)2008/11/07
ISSN Number0036-8075
DOI10.1126/science.1156409
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18988837?dopt=Abstract