Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis.

J Comb Chem
Authors
Keywords
Abstract

The two-step functionalization of 30,000 SynPhase Polystyrene (PS) Lanterns in a 30-L glass process reactor is described. The first step involves bromination of the polystyrene backbone to afford an aryl bromide handle. Subsequent Suzuki cross coupling with the trialkylborane generated in situ from the reaction of allyldiisopropyl(4-methoxyphenyl)silane and 9-BBN provided an alkylsilyl linker ready for loading of various alcohols for solid-phase synthesis applications.

Year of Publication
2009
Journal
J Comb Chem
Volume
11
Issue
1
Pages
110-6
Date Published
2009 Jan-Feb
ISSN
1520-4774
URL
DOI
10.1021/cc8000986
PubMed ID
19049425
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