Scientific Publications

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.

Publication TypeJournal Article
AuthorsBowers, AA, Greshock TJ, West N., Estiu G., Schreiber SL, Wiest O., Williams RM, and Bradner JE
AbstractThe peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.
Year of Publication2009
JournalJournal of the American Chemical Society
Volume131
Issue8
Pages2900-5
Date Published (YYYY/MM/DD)2009/03/04
ISSN Number0002-7863
DOI10.1021/ja807772w
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19193120?dopt=Abstract