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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
|Publication Type||Journal Article|
|Authors||Nilsson, B., Johansson M., Al-Shahrour F., Carpenter AE, and Ebert BL|
|Abstract||MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.|
|Year of Publication||2009|
|Journal||Bioinformatics (Oxford, England)|
|Date Published (YYYY/MM/DD)||2009/04/15|