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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
| Publication Type | Journal Article |
| Authors | Nilsson, B., Johansson M., Al-Shahrour F., Carpenter AE, and Ebert BL |
| Abstract | MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy. |
| Year of Publication | 2009 |
| Journal | Bioinformatics (Oxford, England) |
| Volume | 25 |
| Issue | 8 |
| Pages | 1078-9 |
| Date Published (YYYY/MM/DD) | 2009/04/15 |
| ISSN Number | 1367-4803 |
| DOI | 10.1093/bioinformatics/btp091 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19228802?dopt=Abstract |
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