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Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
| Publication Type | Journal Article |
| Authors | Bowers, AA, West N., Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O., Bradner JE, and Williams RM |
| Abstract | Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access six variants of the side-chain zinc-binding domain, while adaptation of our previously reported modular synthesis allowed probing of the macrocyclic cap group. |
| Year of Publication | 2009 |
| Journal | Organic letters |
| Volume | 11 |
| Issue | 6 |
| Pages | 1301-4 |
| Date Published (YYYY/MM/DD) | 2009/03/19 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol900078k |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19239241?dopt=Abstract |
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