Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.
Org Lett
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Abstract | A regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles with either a 1,5- or a 1,4-triazole resulting in an n or n + 1 ring size. This is the first example of an intramolecular ruthenium-catalyzed Huisgen cycloaddition. |
Year of Publication | 2009
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Journal | Org Lett
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Volume | 11
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Issue | 11
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Pages | 2257-60
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Date Published | 2009 Jun 04
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ISSN | 1523-7052
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URL | |
DOI | 10.1021/ol900562u
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PubMed ID | 19473044
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PubMed Central ID | PMC2702139
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Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
P50 GM069721-07 / GM / NIGMS NIH HHS / United States
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