Scientific Publications

Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.

Publication TypeJournal Article
AuthorsKelly, AR, Wei J., Kesavan S., Marié JC, Windmon N., Young DW, and Marcaurelle LA
AbstractA regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles with either a 1,5- or a 1,4-triazole resulting in an n or n + 1 ring size. This is the first example of an intramolecular ruthenium-catalyzed Huisgen cycloaddition.
Year of Publication2009
JournalOrganic letters
Date Published (YYYY/MM/DD)2009/06/04
ISSN Number1523-7060