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Identifying novel constrained elements by exploiting biased substitution patterns.
|Publication Type||Journal Article|
|Authors||Garber, M., Guttman M., Clamp M., Zody MC, Friedman N., and Xie X.|
|Abstract||Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations.|
|Year of Publication||2009|
|Journal||Bioinformatics (Oxford, England)|
|Date Published (YYYY/MM/DD)||2009/06/15|